Archives-J 

Defective apoptosis (programmed cell death) represents a major causative factor in the development and progression of cancer. Glycogen Synthase Kinase-3 (GSK-3) has the perplexing capacity to either increase or decrease the apoptotic threshold. These apparently paradoxical effects now are known to be due to GSK-3 which oppositely regulating the two major apoptotic signaling pathways. GSK-3 promotes cell death caused by the mitochondrial intrinsic apoptotic pathway, but inhibits the death receptor-mediated extrinsic apoptotic signaling pathway. Consequently, inhibitors of GSK-3 provide protection from intrinsic apoptosis signaling but potentiate extrinsic apoptosis signaling. So, ability of GSK-3 to oppositely influence two types of apoptotic signaling have thrown a light on important regulatory mechanisms in apoptosis and henceforth designing the rational use of GSK-3 inhibitors for therapeutic interventions in cancer.

This article investigates learning strategies among English Language students to what extent they apply the Explicit-Deductive/-Inductive Grammar Learning Strategies in their language learning. The students as the language learners need to acquire precisely the English grammar skills to help them fulfil their course requirements. To achieve the objective of the study, the adopted questionnaire from Language Learner Strategies developed by Oxford and Lee (2011) has been distributed to 95 samples. The findings show that there is relatively strong statistical evidence supporting all the alternative hypotheses by showing that there is a moderately significant relationship between Explicit-Inductive Learning Strategies (EILS) and Explicit-Deductive Learning Strategies (EDLS). 

The main aim of this study has been to assess the variability of groundwater parameters to develop water quality of Sanayapalem area. The ground water is a major source for irrigation in many arid and semi arid regions of India. A total of 30 groundwater samples were collected and analyzed for major cations and anions. The parameters like sodium absorption ratio (SAR), percent sodium, potential salinity, residual sodium carbonate, non carbonate hardness, Kelly’s ratio, permeability index, indices of base exchange and Gibbs ratio were also calculated. Major ionic relationships indicate that weathering reactions have significant role in the hydrochemical processes of the groundwater system. Hydrogeochemical processes controlling the water chemistry are rock- water interaction. Various determinants such as Sodium Absorption Ratio (SAR), Percent Sodium (Na %), Residual Sodium Carbonate (RSC), and Kelley’s Ratio revealed that most of the samples are suitable for irrigation.

Splenic hemangioma is a benign vascular lesion of the spleen that develops at the expense of red pulp structures. It is most often discovered accidentally, radiologically. It often raises a differential diagnosis problem with splenic hamartoma or splenoma, which is defined as a nodular formation consisting of the same elements of normal splenic parenchyma but arranged in a haphazard way.We report the case of a 50-year-old woman hospitalized for pain of the left hypochondrium.

Carbon monoxide is a significant air pollutant worldwide. Its poisoning causes hazards to health and damages in body. This study was conducted in Alkamleen area where a lot of red brick factories are located along the Blue Nile river bank in the east of the area. The study aimed to investigate the hematological parameter about Hb, RBC sand PCV at a high CO concentration area.the study area was divided by two lines parallel to the river bank, 500 meters distance from each other into three zones A, B and C from north to south. Also it was divided from east to west by five imaginary lines to give six squires in each zone. The reading for CO concentration was determined for each square. Blood samples were collected from the habitants in the study area. Hb was determined by the Drab kin’s method, Read by photoelectric colorimeter, RBCs was used improved Neubauer (chamber), to calculate the TRBC, PCV was determined by Micro-Haematocrit centrifuge. CO in air was found to be significantly higher levels of CO concentration in air were detected throughout the year in all zones. Mean+/-SD of RBCs among the study group in winter were 5.6±0.8, Mean+/-SD of RBCs among the study group in summer were 5.2±0.8. Hb, RBCs, PCV were significantly higher for study group in winter as compared to control group.air CO was significantly exceeds the WHO recommended standards. Higher reading in winter and summer of Hb, RBCs and PCV were associated to high CO concentration which emitted from red brick kilns in Alkamleen area.

Nissim Ezekiel position among Indo-Anglian poets of post-Independence era is unique .Nissim Ezekiel’s contribution as a poet in Indian writing in English is very substantial and valuable.He was a Jewish whose forefathers migrated to India and settled in Mumbai. Though a jewish still being born and brought up in India, his poetry contains some aspects of Indianness.Nissim ignored the idea of idealism and romanticism of Indian writers who were influenced by other English writers in India,instead heanalysed Indian situations with Indian attitude. This paper attempts to find out use of Indian Experiences by Nissim Ezekiel and emerging Indianness in his writings Nissim Ezekiel’s contribution to Indian poetry is based on his experiences while living in Mumbai and his his observation and experiences of Indian life and society.His commitment to India flows from his earnest and sincere desire to improve conditions of Life in India.he talks about the depressing, degrading and disgusting conditions of life in India He brings about true picture of poverty in India in his poem Key words: Indianness, language,Culture

This study introduces a inflated multi-layered clustering protocol for ad hoc wireless sensor networks (WSNs), where the size of clusters is variable. So that the closer clusters to the base station (BS) have a smaller size than farther ones. Moreover, in each cluster, using some intelligent fuzzy rules and in a decentralized way, a novel sub tree strategy is determined. In this way, some parent nodes are chosen that are responsible for collecting and aggregating data from their adjacent or dinary nodes and sending them to its cluster head, directly or via other parent nodes, which substantially decreases intra-cluster communication energy costs. Furthermore, these two compatible techniques can fairly mitigate the hot spot problem resulting from multi-hop communication with the BS. The simulation results demonstrate that the proposed protocol outperforms two energy-efficient protocols named DSBCA and LEACH in terms of functional network longevity for both small-scale and large-scale sensor networks.

Soil microinvertebrates are important agents of soil functioning through their bioturbation effects. Termites are found to be distributed with high species diversity in tropical ecosystem. They perform several activities that qualify them as soil engineers. Termite involves in mound building, subterranean tunneling and soil feeding thereby improving soil quality and nutrient fluxes. Subterranean termites Odontotermes obesus and Trinervieus trinervoides modify their environment, increasing the clay and organic matter content ensuring the soil fertility. Free living N2 fixers are found to be associated in termite mound materials. The TMM can be used as biofertilizers and it can improve maize production and economic yield.

There is increased international competition between destinations and hotels and it is apparent that Kenya?s tourism competitive strategies need to be adjusted in order for the nation to be able to successfully compete both locally and internationally. Kenya is a renowned tourist destination competing with countries such as Egypt, Algeria, Tunisia, South Africa, Seychelles and Tanzania. This competition calls for hotels in Kenya to adopt strategies that would give the country advantages over its competitors. To survive, the hotels must be agile enough to respond to the pressures to compete on levels unrivalled in the past. Focus has now shifted to internal processes in order to offer the hotel the best opportunity to take on the unique challenges facing it today. In order for the sector to know if it is competitive in the industry with a lot of competition, implementation of effective competitive strategies is important. The general objective of this study was to assess the influence of competitive strategies on organizational performance of classified hotels in Mombasa County registered under the Kenya Association of Hotel Keepers and Caterers. Specifically, the study sought to determine the influence of competitive strategies on organization?s performance; to assess the influence of market focus strategy on organizational performance and to examine the influence of cost leadership strategy on organizational performance. The study captured the theoretical background on competitive strategies in an attempt to provide basis for appropriate conceptual and theoretical framework for the current study.

The purpose of the study was to investigate teachers’ readiness on the implementation of the competency-based curriculum in private pre-schools in Keiyo North Sub-County, Nairobi City County. The study objective was to establish teachers’ readiness on the implementation of the competence-based curriculum in public pre-schools. The study adopted curriculum implementation theory and descriptive survey design. The target population was 38 public pre-schools, 38 head teachers and 320 pre-school teachers. Simple random sampling was used to select the sample which comprised 108 respondents, 96 pre-school teachers and 12 head teachers. Data was collected using questionnaires. The quantitative data was processed and analysed with the help of the SPSS software programme using Pearson product moment correlation. There was a positive influence of teacher readiness (r = .431) on implementation of competency-based curriculum. This implies that as the teacher readiness improved the on implementation of competency-based curriculum increased. Teachers’ should be adequately prepared in readiness for implementation of a new curriculum through in-service training, seminars and workshops for effective implementation of the curriculum.