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Current anticancer drug development strategies involve identifying novel molecular targets which are crucial for tumourigenesis. The molecular chaperone heat shock protein (HSP) 90 is of interest as an anticancer drug target because of its importance in maintaining the conformation, stability and function of key oncogenic client proteins involved in signal transduction pathways leading to proliferation, cell cycle progression and apoptosis, as well as other features of the malignant phenotype such as invasion, angiogenesis and metastasis. HSP90 inhibitors geldanamycin, geldanamycin derivatives and radicicol exert their antitumour effect by inhibiting the intrinsic ATPase activity of HSP90, resulting inactivation, destabilization and degradation of HSP90 client proteins. HSP90 is new therapeutic target attack on all of the hallmark traits of cancer such as self – sufficiency in growth signals, evading apoptosis, sustained angiogenesis, limitless replictive potential, tissue invasion, insensitivity to anti-growth signals. Clinical activity has been seen with 17-AAG in breast and prostate cancer. Hsp90 inhibitors have entered Phase II and III clinical trials, and have shown therapeutic activity in several types of cancer.

The purpose of this study was to investigate the instructional practices used among teachers and students in teaching Citizenship Education through History and Government at the secondary school level. The study adopted qualitative research with a multiple case study design. Data was collected using Observation schedules, interview schedule and focus group discussion guide. Data was analyzed using grounded theory and constant comparative technique. The finding of the study revealed the domination of classroom activities over outdoor activities. The study recommends for a curriculum review to introduce competence learning that will enhance the use of both classroom and outdoor activities.

Cadmium zinc sulfide (CdZnS) thin film was deposited on transparent conduction Indium tin oxide (ITO) coated glass substrate by a cost effective chemical bath deposition (CBD) method. Commercially purchased ITO coated glass substrate with sheet resistance 8 ?/cm2 was utilized for the deposition of CdZnS thin film under optimized chemical bath conditions. Surface texture of the fabricated CdZnS thin film was analyzed by atomic force microscopy (AFM) and scanning electron microscopy (SEM) analysis. The optical absorption and transmittance properties of the fabricated CdZnS thin film was investigated by UV-Vis spectroscopy in the wavelength range of 300 to 1100 nm. The investigated surface and optical properties of the fabricated CdZnS thin film towards optical applications are presented and discussed.

Judicial Reforms need to take place in an integrated manner and important because the public has lost faith in the system. The police, prosecution, lawyers and courts, must be thought of as being cohesive and everyone is concerned about the large delays in disposal of cases, and the agenda for judicial reforms must first tackle the problem of this backlog. Law Commission Reports and formation of tribunals to take away some of the workload of High Courts, but still, High Courts are burdened with a large number of cases. Increasing the manpower in judiciary is the need of the hour. Also, the problem faced by the judiciary can be solved, it is an urgent need for improvements in the physical infrastructure available to the judiciary, the state of legal education as well as Continuing Legal Education (CLE) in India and last but not the least, the continuing debate about judicial accountability.

Students’ satisfaction has become an essence of success in today’s highly competitive world. In service industry specifically the education industry, communication is vital to determine students’ satisfaction. Past researches indicated that, most meaning of conversational messages comes from non-verbal communication. Evaluation on students’ perception on lecturers’ kinesics that would lead to their satisfaction to the services provided was examined. The results of the study illustrate that kinesics that is also known as body movements was shown to have the most impact on students’ satisfaction. Therefore, from this study, it can be inferred that students’ in Malaysian universities are mostly observant on the body movements used, facial expression and postures and gestures of the body of their lecturers when lectures are delivered to them. The present study caters for a wide spectrum of students and development professionals, especially those who are interested in non-verbal communication specifically kinesics-related issues. It is highly hoped that the information gleaned from the present study may assist all service employees specifically in understanding better, the importance of kinesics and its effects on students’ satisfaction.

Docetaxel stabilizes microtubules while inhibits mitotic spindle formation. It has been found to be effective in treating several solid cancers. The aim of this study was to in cooperate docetaxel in conventional and Chitosan coated liposomes, and to evaluate the antiproliferative effects of different formulations on MCF-7 and HepG-2 cell lines. MTT assay was used to determine the growth inhibition of the cell line by docetaxel. A significant dose-dependent inhibition of proliferation was found after the cells were exposured to certain liposomal docetaxel preparations, suggesting the possible use of liposomes as effective docetaxel delivery devices.

Offshore wind and tidal current are of the most common energy resources for generating electricity in the near future because of the oil problems (crises and pollution). The dynamic model of the offshore wind and tidal current are very important topic for dealing with these renewable energies. This paper describes the overall dynamic models of tidal current turbine using three different types of generators (doubly fed induction generator (DFIG), squirrel cage induction generator (SCIG) and direct drive permanent magnet synchronous generator (DDPMSG)). The state space for all types of the generators of these two types of turbines are concluded. All models are validated using a common property of the generator for the validation.

Brain is a highly vascular organ and receives about 15% of cardiac output. The Circle of Willis (CoW) or Circulus arteriosus is a ring-like arterial structure located at the base of the brain. The circle of Willis has its greatest significance in collateral circulations of the brain specially in old people who may have reduced brain blood supply due to senile arteriosclerosis. Materials and methods: The study was therefore conducted on 20 brains obtained during routine anatomical dissection in the department of Anatomy. The formative pattern of the circle of Willi’s external diameters of internal carotid arteries were measured, length of the anterior communicating was also recorded. Results: Out of twenty specimens studied, 8 specimens showed variations in the formative pattern of circle of Willis. Like The basilar artery continued as Left posterior cerebral artery, Right posterior cerebral artery arising was from right internal carotid artery with Bilateral absence of Posterior communicating artery , right posterior cerebral artery was arising from Right internal carotid artery. Bilateral fetal type of Posterior cerebral arteries. A long anterior communicating artery of about one cm (10mm) was also observed in one of the cases. Though variations of the arteries at the base of the brain are common, it is necessary to be aware of all the variations as they may breed problems in the blood flow to the brain and may cause confusions in radiological procedures.

For high bit rates and long haul optical communication systems using a single-mode fiber, a modulator with low chirp and small size are demanded. An electro-absorption modulator is very attractive because it has some advantages of not only low chirp and small size but also the elimination of polarization control through monolithic integration with a distributed feedback (DFB) laser. The modulation bandwidth of traditional lumped electro-absorption modulators (EAMs) is usually limited by the RC time constant, but the effective resistance R and capacitance C are not easily extracted for advanced device geometries. This paper has presented the important transmission characteristics of EA modulators such as transmission performance efficiency, insertion loss, extinction ratio, , over wide range of the affecting parameters for different selected electro-absorption materials to be the major of interest.

Whether Oil price changes have an impact on the Stocks of KSE (Karachi Stock Exchange) or not? This study examines impact or relationship of Oil prices on stock returns with reference to KSE (Karachi Stock Exchange) Pakistan. Weekly data ranging from January 1998 to October 2010 is included and tested in this paper. This relationship is tested by using Descriptive Statistics and Correlation Matrix. Data Stationary is ensured by Unit Root Test. Evidence from Granger Causality and Impulse Response Test. The Results shows that Oil prices and shares prices in Pakistan has no long term relationship or impact on each other focusing on the data of KSE (Karachi Stock Exchange).