Archives-June... 

Colon is an ideal site for delivering drugs for both systemic and local action. The aim of the study is to formulate a sustained release tablet dosage form for theophylline, which is used for treating nocturnal asthma. Theophylline tablets were prepared by direct compression method and coated with Eudragit S100 and HPMC inorder to avoid the drug release in the upper gastro intestinal tract. Tablets were characterized by the following parameters like hardness, friability, film property, weight variation, uniformity of drug content and in vitro dissolution studies were performed by half dilution method. The coated tablets remain intact drug release up to 5 hours. An accelerated stability study was carried out at ambient condition and 45ºC with 75% relative humidity. In conclusion the coated theophylline tablets was found to be better alternate for the conventional tablets to release the drug in the mid night and early in the morning which is desirable features for treating nocturnal asthma.

The ophthalmic solution with minimum concentration of preservative preparation in an appropriate packaging material appears to be most attractive approach for the process development and scale-up point of view. A simple high performance liquid chromatographic (HPLC) method for the simultaneous determination of ofolaxin in eye drops formulation was presented. Benzalkonium chloride in concentrations from 0.1% to 0.0001% induced dose-dependent growth arrest and conjunctival epithelial cell death, either delayed or immediately after administration The HPLC separation was undertaken on a inertsil C18 column using a mobile phase of water for injection. Compatibility study was assessed through measurement of factors affecting column peak symmetry, calculated using peak area and peak height of chromatogram. Assay decreased from 104 % to 102.89 % in three pieces to 101.27% in BFS, and 102.24 in glass container. Chromatographic analytical data indicated the stability of parenteral preparations in containers good enough till three months.

In the present paper, the classical generalized Hardy type transformation depending on three real parameters defined by where with and denote the Bessel type function of first and second kind of order respectively is extended to certain spaces of generalized functions by the kernel method in such a way that the theory of Pathak and Pandey [11] in relation with Hardy type transformation appears then as a particular case for . By interpreting the convergence in the weak distributional sense, an inversion theorem is established. The theory thus developed is applied to solve certain boundary value problems.

Water has been a precious resource for human life. The extent of utility of water resource for any purpose is dependent on a variety of factors like economic development, standard of living, industrialization and agriculture practices in a particular region. The ground water is a major source of domestic and agricultural activities in the present study area. The study area is classified into two divisions, the northern Command area and the southern Non-command area both lying in the same climatic region. The Command area is occupied by limestones and the Non-command area by hills of Quartzites, Phyllites and Shales. The results revealed that ground waters in the study area are slightly alkaline in nature. In terms of potability, although, concentrations of many parameters are within the limits of dirnking water quality standards (WHO (1993), ISI(1991) the ground water of the area is effected by the excess of salinity content, the excess of which can cause gastrointestinal problems to the local population.

Breast cancer is the most commonly diagnosed cancer in women and it is the leading cause of cancer deaths among women. Breast cancer has arisen as the most commonly detected cancer among women in sub-Saharan Africa, exceeding cervical cancer. This study sought to specifically assess the knowledge levels of female Senior High School (SHS) students of breast cancer and breast self-examination. It was also to ascertain whether females in Senior High Schools practiced Breast Self-Examination (BSE) and the barriers to practicing BSE. The study utilized quantitative method; the cross-sectional design was used to investigate the knowledge of breast cancer and practice of breast self-examination. The Bolgatanga Girls' Senior High School was used; they had a total population of 1, 946. Simple random sampling was used to choose students in year three who were 600. A sample size of 260 students were chosen for the study. The study showed that students had low knowledge of breast cancer risk factors and breast cancer screening methods however, they had high knowledge of breast cancer signs and symptoms. More than half of the respondents never performed BSE. Statistical Package for Social Sciences (SPSS) version 21 was used to analyze the data. Despite high awareness of breast cancer and BSE, in-depth knowledge is low and respondents' BSE practices were characterized by faulty timing and regularity. It was recommended that there was the need to intensify education of the young girls on breast cancer and BSE for early detection and management.

Inclusive education is burning issue of the present world and inclusive education is in its initial stage in Pakistan. This study was conducted to know the perception of mainstream school education teachers on different (psychological, social, academic, and general) and comparison of rural and urban areas mainstream teachers’ perception towards inclusive education. Total 90 teachers were the participants of this study. Data were collected personally by researcher on self-developed questionnaire on four domain; Psychological aspect, social aspects, academic aspects and general aspect. The collected information were analyzed through percentage, mean, SD, and t-test. The overall results of the study indicated that the majority of teachers have positive perception towards inclusive education, but it is necessary for proper preparation, training and facilities for better implementation.

The salivary glands stand out as the tissue with probably the most diverse pathology in the human body. Salivary gland tumors are abnormal cells growing in the ducts that drain the salivary glands. Benign tumors are more common with the major glands. This review highlights management of benign epithelial salivary gland tumors. This covers various types of parotidectomy and techniques of submandibular gland excision. Endoscopic approaches and sialendoscopy are the recently used modalities.The key to surgical success is early identification of the facial nerve, meticulous dissection, and eradication of all disease at the time of initial surgery.

In this report a case of periprosthetic fracture of femur associated with diabetes mellitus since 10 years, 2years ago, she was operated with A.M prosthesis for neck right femur fracture. It takes into account the site of the fracture, the stability of the implant, and the surrounding bone stock, which are the important elements of the fracture and hip that determines treatment.

In any business, large or small, the adoption of competitive strategies is imperative. Sales generate profits – in turn profits allow for growth. Financial institutions, especially in developing markets, use agents to reach an additional client segment or geography. However, many companies have found the application of competitive strategies difficult to properly implement due to lack of adequate understanding and preparation by management and agents. Hyper-competition is characterized by intense and rapid competitive moves, in which competitors must move quickly to build new advantages and erode the advantages of their rivals. Factors that have led to accelerated hyper competition include knowledge sharing (franchise and outsourcing), brand convergence, quick niche copying (imitation), and high quality resulting from standardization, shrinking markets, and attraction of powerful new entrants to business segments with high returns, Yet the astonishing reality is that most of the firms are as unprepared for the challenges of finding, motivating, and retaining capable workers as they were a decade ago. Business leaders are deeply concerned with increasingly global nature of that competition - to have a major effect on their companies. Specific focus for this study is dedicated on theoretical and empirical literature, on organizational and institutional competitive strategies applied within management and concludes with a conceptual framework. Literature reviews consists of details of published and unpublished documents such as journals, papers, books, e-sources and other accredited researchers on related topics.

Moderated mediation has been proven to be one of the useful techniques in providing powerful analysis in many research areas such as social science, statistics, marketing, health science and others. By using secondary data obtained from Trends In Mathematics and Science Study (TIMSS), moderated mediation analysis is used to determine the significance difference of direct effect and total effect including indirect effect of exogenous latent constructs toward endogenous latent construct through mediator latent construct between moderator; male and female samples. From the Moderation Analysis, it is found that there is no significant difference between male and female samples in the direct effect of all exogenous latent constructs toward endogenous latent construct. The same result obtained in Moderated Mediation Analysis where there is no significant difference between male and female samples in the total effect including indirect effect from all exogenous latent constructs toward endogenous latent construct through mediator latent construct.