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The aim of the present study was to design and develop a self microemulsion drug delivery system (SMEDD) of Atorvastatin Calcium and evaluate its release kinetics by using mathematical models. Suitable oil, surfactant and cosurfactant were selected based on the solubility, HLB value and biocompatibility. Pseudo-ternary phase diagrams were constructed to identify the microemulsion existing zone and to get a tentative surfactant to cosurfactant ratio. Atorvastatin Calcium loaded SMEDD was developed and characterized for particle size, zeta potential, surface morphology, drug entrapment and comparative in vitro drug release study. Different dissolution models were applied to drug release data in order to evaluate release mechanisms and kinetics and the criterion for selecting the most appropriate model was based on linearity (coefficient of correlation). % Transmittance, Particle size and zeta potential of the formulation containing Labrafac PG as oil, Accenon CC as surfactant and Transcutol P as cosurfactant were found to be 99.87%±1.2, 31.82 nm± 1.15 and -15.8 mV± 1.13 respectively. The drug release data fit well to Koresmayer Peppas equation plot (r2 =0.981) indicating the dissolution rate limited drug release from a SMEDD formulation. Drug release mechanism was found as a Super case-II transport, (i.e., n value-1.229).

It has been widely reported that cochlear implantation has had a dramatic effect on language competence among young profoundly deaf children. Thanks to this revolutionary device, language competence, speech intelligibility and conversational fluency among this category of children are now attainable by many of those who previously depended on sign language to communicate. However, due to the considerable variability and large individual differences in the performance outcomes of many other children, it has become commonly believed that motivating cochlear-implanted children who have learning spectrum disorders is a basic but hard challenge. It is a fundamental challenge because these children experience hearing and perceive speech for the first time after the rehabilitation of their hearing skills. Such skills are undeniably necessary for community living and coping. It is a hard challenge because children with cochlear implants by and large are vulnerable to diverse factors internal and external which impact their learning unless positive and successful experiences are planned. The following questionnaire-based paper is an attempt to address one of the challenges associated with motivating cochlear implanted children, namely, resistance to learning. It also aims to explore different behaviors that manifest this phenomenon, explain its possible reasons and highlight its major implications.

Enterprise informatization is a procedure in which IT is applied into the field of enterprise production, technology, and management, to improve the cost-effectiveness of exploration of informational resources and obtain financial profits. Enterprise informatization consists of three main aspects, the automation and flexibility of production, the integrative management and the systemic organization. The capacity of enterprise informatization is a resources-based capability, which has technical, manageable and organizational properties; it is divided into the three categories, which include information technology capability, information organizing capability and information innovation capability. Enterprise informatization capability can improve business performances, in this study we do the research on informatization capability how to increase enterprise’s competitive advantages in synergy, integration of customer relationship management, e-supply chain management, as well as global opportunities.

Education is bound to be affected if safety and security concerns of students are not addressed fully. The objective of the study was to determine the role of financial resources in implementation of school safety measures in public boarding secondary schools in Trans- Nzoia County, Kenya. The study used descriptive survey research design. The study targeted 754 teachers from 40 public boarding secondary schools in Trans-Nzoia County. stratification and simple random sampling were used to select boarding secondary schools. The total sample was 143 teachers. Questionnaires were used as data collection instruments. Data was analysed using descriptive statistical techniques that were frequencies and percentages. Data was presented in tables. The study found out the ministry of education had no provisions for allocation of funds to take care of safety needs and requirements in the institutions. It ascertained that the secondary schools have vote heads allocated for the purpose of catering for the safety needs and requirements though in many instances the schools diverted the funds to other needs that they felt were more pressing owing to situation of shortfalls in financing and budgetary deficits. The government through the Ministry of Education should ensure that Standard Safety Guidelines are availed to all schools and the schools be allocated sufficient funds to be able to implement the guidelines. Funds should always be availed at the required times to allow for the provision of infrastructure for safety requirements and the allowing of purchase of tools and implements for safety needs.

The movement of people from one society to another society is called migration, this may be contemporary or permanent basis. This study assessed the consequences of rural-urban migration on the source region of Ughievwen clan in Ughelli South Local Government Area. secondary sources data were collected from journal publications and other published materials from textbooks and official gazette. The findings of the study show that females migrate more than the males in Ughievwen and migration is high within the age cohorts of 15-25 years and 26-35 years. Moreso, migration decreases with age, and this may be due to the higher psychological cost for migration associated with older people. Most of the persons in the community had acquired just their basic education. Thus, most of them are willing to migrate to major cities to obtain higher education. It has been widely observed that the propensity to migrate increases with education. Furthermore, the study revealed that migration is affected by socioeconomic, demographic and cultural factors. It was recommended that functional social amenities such as electricity, pipe borne water should be provided in the rural areas as a way forward against rural-urban movement

The school environment is one of the most important factor, in promoting learning at every stage of school life. If the environment is conducive, learning accelerates with time and age, that is true for CWSN too. School environment for ‘Children with special need’ consist of infrastructural design of the school, physical resources available at school, the academic resource available at classrooms and school, the behaviour of peers, seniors, school staff and teachers. It has been found that infrastructural facility like pathways, boundary wall, classrooms, toilets, drinking water improves CWSN enrolment as well as attendance. Analysis of data also demonstrates that beautification of school, cleanliness, behaviour of peers/teachers/support staff improves students engagement in school and learning. Teaching-learning aid of every kind support CWSN in engaging themselves in learning.

Cerebral germinoma represents i0.1 to i3.4% of intracranial tumors with a clear male predominance, it is developed more particularly in the pineal region. iIt most commonly affects adolescents and young adults. This type of tumor responds highly to radio-chemo-therapy and is potentially curable after surgery.

A separation cordial labeling of graph is a bijection f from to such that each edge uv is assigned the label 1 if ) is an odd number and label 0 if is an even number. Then the number of edges labeled 0 and the number of edges labeled 1 differ by at most 1. A graph has a separation cordial labeling, then it is called separation cordial graph. Here, the bistar the splitting graphs of and , the shadow graph of and square graph of are discussed and found to be separation cordial.

Seismic wave propagation through acoustic medium allows us to understand response through a fluid saturated medium. This interaction has been described by the acoustic wave equation. In this work, the acoustic wave equation was written in coupled form and was discretized using the staggered grid finite difference (SGFD) method, which provides improved accuracy and efficiency of the numerical modeling and are naturally centered at the same point in space and time. To truncate artificial reflections from our computational boundary, we have applied the perfectly matched layer (PML) absorbing boundary condition. Our results show seismic wave propagating through a homogeneous medium and the effect of PML was clearly observed.

Participation is a phenomenon that has long been associated with the evolution of human life, but in the 1950s and 1960s, when imported programs from the West to developing was failed because of lack of people participation, regarding to this phenomenon and emphasis on its role as an agent of development was increased and after that, the foundation of development strategies, community participation approach was formed as a basic human need. Regarding to the importance of the topic in this research by using field method, techniques and survey questionnaire sought answers to this question” Social and cultural factors involved in the construction of mosques and religious site, what are people? Given the importance of social and cultural factors involved in the construction of mosques and popular religious site in this study to analyze the relationship between variables such as socio-economic status of family, religion, social trust, sex, age, and education as independent variables and relationships it was a turnout as the dependent variable. The results indicate that among all the independent variables with the dependent variable, there was a direct and significant relationship.