Archives-  

Swine flu (swine influenza) is a respiratory disease caused by viruses (influenza viruses) that infect the respiratory tract of pigs and result in nasal secretions. Swine flu produces most of the same symptoms in pigs as human flu produces in people. The 2009 swine flu strain, first seen in Mexico, is termed novel H1N1 flu since it is mainly found infecting people and exhibits two main surface antigens, H1 (hemagglutinin type 1) and N1 (neuraminidase type1).This study deals with the structure prediction and computer aided drug interaction studies for the neuraminidase protein from H1N1 virus. Selection of neuraminidase was done since its function is to move the virus out of host cell and hence spread more disease. Targeting this protein with potential drug compounds will stop further spread. Accelrys Discovery studio 2.5 was the software employed in this work. Target sequence selection was done from PIR database and homology modeling was carried out using in-build modeler in DS. Quality of the model has been analyzed and binding sites were predicted. Drugs suitable for swine flu were retrieved from drug bank and through a 3D database search in DS, different conformations has been developed. Molecular docking was performed using Ligandfit in DS. Selection of best drug was done based on highest dock score which was further studied for ADMET (Absorption, Distribution, Metabolism, Elimination and Toxicity) properties. TOPKAT predictions, which give results for carcinogenicity, ocular irritation, skin irritation was also carried out. The results of this study can be useful further for QSAR studies and various in-vitro analysis later.

Prolonging lifetime of WSN is a critical issues today. For overcoming this issue a good WSN design needed to be energy efficient. Routing is one of the reasons for reducing the lifetime of WSN. By using energy aware routing algorithm we can maximize the life of the network. In this paper we have used load balancing ACO algorithm with TARF to overcome energy problem in WSN. This algorithm help in providing shortest path reduce energy and time consumption and provide security against attacks.

In this study, the deformation behavior of 93Tungsten alloy under the hydrostatic extrusion has been investigated. The hydrostatic extrusion process of 93 Tungsten alloy has been analyzed by means of finite element method (FEM). The numerical results were highly corresponded to the experimental ones. Also the effect of die angle on the extrusion pressure and applied damages to the 93 Tungsten alloy during the process of hydrostatic extrusion has been investigated according to the Cockcroft & Latham damage criterion. As was deduced from results, when the die angle has been considered as 30°, the applied damages to the material during the process were negligible in comparison with higher values of die angle.

The vibrational spectral analysis was carried out by using Raman and infrared spectroscopy in the range 4000–400 cm?1 and 4000–100 cm?1 respectively, for 2-amino-5-nitropyrimidine (2A5NP) molecule. The molecular structure, fundamental vibrational frequencies and intensity of the vibrational bands are interpreted with the aid of structure optimizations and normal coordinate force field calculations based on density functional theory (DFT) method and different basis sets combination. The complete vibrational assignments of wavenumbers were made on the basis of potential energy distribution (PED). The scaled B3LYP/6-311++G results show the best agreement with the experimental values over the other methods. The calculated HOMO and LUMO energies shows that charge transfer within the molecule. The results of the calculations were applied to simulate spectra of the title compound, which show excellent agreement with observed spectra. Electronic excitation energies, oscillator strength and nature of the respective excited states were calculated by the closed-shell singlet calculation method were also calculated for the molecule.

The study investigates the significant determinants of stock returns of all non-financial listed companies in Karachi Stock Exchange (KSE), Pakistan from 1998-2011 by using panel data techniques. In addition, this study further categorized into Syariah and Non-Syariah compliant firms to examine the significant differences of stock determinants. All listed stocks in Karachi Meezan Index (KMI) are entitled as Syariah complaint firms, rest of the firms listed in KSE all index are identified as non-Syariah complaint firms. As Syariah complaint firms don’t use any unethical means to cater its stock prices, so, it was hypothesized that Syariah stocks follow the fundamental of the companies. Size, book to market, leverage, dividend yield, earning to price, cash flow to price and discretionary accrual represents the fundamentals while market premium, stock price volatility and trading volume indicates the stock market variables. Fixed effect model and Random effect model is applied for statistical estimations. Hausman test is further used to find the most significant model. Modified wald test find the heteroskedasticity, final results were robust to counter the heteroskedasticity issue. The results of all non-financial listed firms confirmed the significant positive market premium, size, stock price volatility and trading volume whereas significant negative book to market ratio. Market premium, leverage and stock price volatility are the only significant determinants of Syariah complaint firms. Insignificance of BM and TV confirms that Syariah stocks follow the fundamentals instead of noise trading. In a nutshell, Syariah complaint firms respond to fundamentals although non-Syariah complaint firms follow noise trading in Pakistani context.

Education in general and language education in particular usually poses great problems to those who don’t have a favourable academic environment. The case of ESL/EFL/ESOL is always a challenging task. English in most Arabic speaking countris serves a very limited purpose. Yet, it is very important for social as well as technological development. Therefore, English language teaching (ELT) in such countries also catches attention of many researchers. ELT generally starts at the school level. Despite good overall planning, purposive curriculum, integrated textbooks, qualified teachers, the achievement is below the expectations. Therefore, diagnostic studies should better be undertaken in different language areas: sound system, vocabulary, meaning, grammar and various skills so that the teacher may know the types of the problems and the corresponding factors. Such attempts are expected to be helpful in possible evolution of some fruitful and compatible strategies in order to yield the maximum academic output.

Digitalis (cardiac glycosides) is a naturally occurring substance in various plants (digitalis, squill). They are mainly used in the treatment of heart failure and cardiac rhythm disorders. They induce a positive inotropic effect by inhibiting NA+/K+-ATPase which results in an increase in the amount of calcium released from the sarcoplasmic reticulum in each cycle of contractions. Digitalis toxicity is a rare drug complication, but potentially serious. This is rare when good rules of drug prescription are respected, though this is not often the case. This highlights on the need for further information to physicians and their patients about the risk involved, including renal failure and electrolyte imbalance (hypercalcemia, hyperperkalemia, hypokalemia etc.).

The global financial crisis, brewing for a while, really started to show its effects in the middle of 2007 and into 2008. Around the world stock markets have fallen, large financial institutions have collapsed or been bought out, and governments in even the wealthiest nations have had to come up with rescue packages to bail out their financial systems. Indian economy began to slow down in 2007-08 (April-March) after reaching a GDP growth of 9.8 per cent in the last quarter of 2006-07. In fact, Indian economy grew at an annual average rate of 8.8 per cent during the five years ending 2007-08. In the first half of the financial year 2008-09, the growth rate dropped to 7.8 per cent. The global crisis has hit India through a “sudden stop” of capital inflows and a collapse of both external and domestic demand. The growth of the economy dropped to 6.7 per cent in 2008-09 from 9.0 per cent in the previous year and is slowly increased to 8% in 2009-10 and 8.5% for the financial year 2010-11. The present paper is an attempt to analyze the impact of global recession on Indian economy, how the Indian economy recovered and also analyze whether the global crisis still influencing the Indian economy

The objective of this work is to study the efficiency of some surface modified phyllosilicate minerals (bentonite and glauconite) in the removal of dyes from textile waste water. It is found that complete dye removal was achieved by using (10-25) g modified glauconite from solutions having a dye concentration of 10-50 mg/L. Adsorption data were modeled using Langmuir, Freundlich, Temkin and Dubinin-Radushkevich isotherms. Adsorption capacities and optimum adsorption isotherms were predicted by linear regression method. The analysis of experimental isotherms showed that Langmuir isotherm reasonably fit the experimental data in the studied concentration range for the adsorption of dye onto glauconite mineral surface where Freundlich isotherm fit the experimental data for the adsorption of dye onto bentonite mineral surface.

The effect of cassava peel ash on Lateritic Stabilized with Bitumen was investigated. The lateritic solid was collected from Umuma-Isiaku in Ideato South LGA of Imo State. The Bitumen was collected from New Idea Construction Company Ltd in Owerri. The Cassava peel was collected from Ohaji in Egbema LGA OF Imo State. The Cassava Peel was burnt in a furnace and sieved with 150% sieve to obtain the ahs used in the experiment. The lateritic soil was classified as A-2-7 on AASHITO classification chart. The percentage replacement level of soil by Bitumen and Bitumen/cassava peel ash 0-10% by weight of dry soil. The investigation was carried out with respect to compaction Characteristic and California Bearing Ratio (CBR) tests. The result obtained indicated a decrease in maximum Dry Density (MDD) when the soil was stabilized with bitumen and increases when cassava peel ash was incorporated for 0-10% replacement level of soil with bitumen and bitumen/cassava peel ash respectively. The result of the optimum moisture content (OMC) increases when bitumen was used in stabilizing the soil and decreases when cassava peel ash was incorporated. The result of the MDD when bitumen was used in stabilizing the soil ranges from 2.16-1.76gkmcm3 for 0-10% replacement of dry soil with bitumen and 2.16-4.20g/cm3 when cassava peel ash was incorporated. The results of OMC ranges from 11.20 -21.90% and 11.20-8.80% for 0-10% replacement of dry soil with bitumen and bitumen/cassava peel ash respectively. The result of CRR text ranges from 22.66-85.75% and 22.66-18.10% for the same replacement level of bitumen and bitumen/cassava peel ash respectively. These results shows that the high shear strength of soil which was achieved by stabilizing the soil with bitumen was reduced by the incorporation of cassava peel ash.