Recent Trends in Hazards in the Pharmaceutical Industry and Safety Precaution
Hazards is a situation that posses a level of threat to life, health, property or environment. Any real or potential conditions produced by industries that can cause injury or death to personnel or loss of product or property. Industrial hazards is a major issue in present scenario. Some industrial plants, by the nature of their activities and the substances they use, constitute hazards which are all the greater when they are located close to residential areas for these and their residents are particularly exposed in the events for accidents. Industrial hazards may be defined as the contamination of the Pharmaceutical industries that may cause irritation, toxicity and damage of the product, which are also harmful for product quality in the Pharmaceutical Manufacturing.
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Vitamin-B1 An Environmentally Benign Catalyst for the Synthesis of 14-Aryl-4h-Dibenzo[A,J]Xanthenes Under Solvent-Free Conditions
Thiamine hydrochloride (VB1) has been used as an environmentally benign catalyst for one pot synthesis of 14-aryl-4H-dibenzo[a, j]xanthenes derivatives by the three-component reaction of two equivalants of ?-naphthol and aldehydes at 1100C under solvent-free conditions. Various type of aldehyde bearing electron donating as well as electron withdrawing substituents underwent smooth reaction under the optimized reaction conditions and products were obtained in good to excellent yield.
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Reduction of greenhouse gas emissions of eggplant production by energy optimization using DEA approach
The main objective of this study was the determination of optimum energy requirement and potential of greenhouse gas (GHG) reduction of eggplant production by non-parametric method of data envelopment analysis (DEA) in Guilan province, Iran. The BCC and CCR models of DEA were applied to energy optimization. The results showed the 29, 39 and 30 units had the score equal one in technical, pure technical and scale efficiency, respectively. Also, the average of technical, pure technical and scale efficiency was calculated as 0.771, 0.956 and 0.806, respectively. The total saving energy was about 2830 MJ ha-1 and diesel fuel had the highest share of total energy saving with 48.49%. The energy use efficiency of target units was more than present units about 26%. The GHG emissions analysis indicated that total GHG emissions of present and optimum units were about 515 and 401 kgCO2eq. ha-1, respectively. So, the total potential of GHG emissions reduction was found about 115 kgCO2eq. ha-1. Moreover, the diesel fuel had the highest percentage of GHG emissions reduction by 58.58%; followed by machinery with 17.24% and nitrogen with 15.12%. Generally, it can be said the DEA approach was appropriate methods for energy optimization and reduction of GHG emissions in eggplant production.
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Corporate social responsibility and risk management of multinational companies: a case study of body shop
The present research paper formulated a conceptual framework for multinational companies to manage their risks with the help of corporate social responsibility initiatives and efforts. The case study of The Body Shop is analyzed for this purpose using the corporate social responsibility pyramid. The different corporate social responsibility initiatives and practices of The Body Shop were analyzed to determine which risks were being managed by those initiatives. The results of the present study showed that an organization can increase its output by reducing its risks associated with operations through corporate social responsibility activities related to environment, health and safety. Other risks including compliance and strategic risks can be catered to with the help of corporate social responsibility.
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Detection of protease from latex producing plant by X-ray film by DOT-BLOT method
Many plants contain latex that exuded when leaves are damaged & number of protein & enzymes have been found in it. The latex of some plant families such as Asclepiadaceae, Apocynaceae, Caericaceae, Euphorbiaceae, Moraceae, Meliaceae, Sopodilla contains endopeptidase. In presence study fourteen various latex producing plants were identify for the presence of proteolytic activity by dot-blot X ray film method. The Euphorbia synudenium, Caloteopisprocera, Thevetia Peruviana, Ficusreligiosa, Caricapapaya, Azarirachta indica, Ficusbengalensis, Manikarazopota, caloteopisgigantea, degrade the gelatin on the x-ray film & the clear zone is formed at the site of application on x-ray film which indicates the presence of protease in the sample. The Jatrophacurcus, Plumeriarubera, Euphorbia triucalli, Ficusracemosa, Ricinuscommanis show no zone of clearances at the site of sample on x-ray film which shows absence of protease. The protein estimation of a various latex containing plants were done by lowery‘s method. The Euphorbia synudenium ,Caloteopisprocera, Thevetiaperuviana, Ficusreligiosa, Caricapapaya ,Azarirachtaindica, Ficusbengalensis, Manikarazopota, caloteopisgigantea, Jatrophacurcus, Plumeriarubera, Euphorbia triucalli Ficusracemosa, Ricinuscommanisin show protein concentration in between the rang of 45µg-390µg/ 0.1ml respectively. The proteolytic activities of enzymes preparation isolated from latex containing plants were estimated by using casein as substrate.In the present paper we described a simple and inexpensive procedure to detect protease of latex containing plants by the X- ray film dot-blot method.
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Recent advances in parenteral drug delivery system
Drug delivery is a multidisciplinary field. Researchers recently developed a drug-delivery system to mitigate some problems associated with jet-injection drug delivery, and also improved on the design and operation of microscale actuators as a possible drug-delivery methodThe Parenteral administration route is the most common and efficient for delivery of active drug substances with poor bio-availability and the drugs with a narrow therapeutic index. But parenteral route offers rapid onset of action with rapid declines of systemic drug level. For the sake of effective treatment it is often desirable to maintain systemic drug levels within the therapeutically effective concentration range for as long as treatment calls for.Parenteral drug delivery systems are the preparations that are given other than oral route. (Para-outside, enteric–intestine). Parenteral drug delivery systems are most preferred drug delivery systems as they meet many benefits over other dosage forms in many cases such as unconsciousness, nausea, in emergency clinical episodes. The Parenteral administration route is the most common and efficient for delivery of active drug substances with poor bio-availability and the drugs with a narrow therapeutic index. But Parenteral route offers rapid onset of action with rapid declines of systemic drug level. For the sake of effective treatment it is often desirable to maintain systemic drug levels within the therapeutically effective concentration range for as long as treatment calls for. It requires frequent injection, which ultimately leads to patient discomfort. For this reason, drug delivery system which can reduce total number of injection throughout the effective treatment, improve patient compliance as well as pharmacoeconomic.
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A Proposed method for designing an intelligent system for optical handwritten character recognition
The accurate recognition of Latin-script, typewritten text is now considered largely a solved problem. Typical accuracy rates exceed 99%, although certain applications demanding even higher accuracy require human review for errors. Other areas—including recognition of hand printing, cursive handwriting, and printed text in other scripts (especially those with a very large number of characters)--are still the subject of active research. Recognition of cursive text is an active area of research, with recognition rates even lower than that of hand-printed text. Higher rates of recognition of general cursive script will likely not be possible without the use of contextual or grammatical information. For example, recognizing entire words from a dictionary is easier than trying to parse individual characters from script. Reading the Amount line of a cheque (which is always a written-out number) is an example where using a smaller dictionary can increase recognition rates greatly. Knowledge of the grammar of the language being scanned can also help determine if a word is likely to be a verb or a noun, for example, allowing greater accuracy. The shapes of individual cursive characters themselves simply do not contain enough information to recognize all handwritten cursive script accurately (greater than 98%). It is necessary to understand that OCR technology is a basic technology also used in advanced scanning applications. Due to this, an advanced scanning solution can be unique and patented and not easily copied despite being based on this basic OCR technology. In this paper, an intelligent system for “OPTICAL CHARACTER RECOGINITION” using Artificial Neural Network based approach and a Feature Extraction algorithm before an ANN can be applied for classification of characters which promises to provide increased efficiency for the character recognition is proposed.
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Antitumour activity of Microencapsulated Paprika Oleoresin In vivo on Ehrlich ascites carcinoma in mice
Paprika oleoresin, obtained from capsicum species is used as a natural colourant and flavour enhancer in food and pharmaceuticals and is shown to be effective free radical scavengers including potential antioxidative and anticancer properties. The current investigation aims to evaluate the anticancer activity of developed MPO (Microencapsulated Paprika Oleoresin) on EAC tumour model. Male Swiss albino mice were divided into 6 groups (n=12). Group I (normal) animals received normal saline solution orally, all the other groups (Group II to VI) were injected with EAC cells (0.2 ml of 2 x106 cells/mouse) intraperitoneally. MPO at different doses such as 0.5, 2.5 and 5 mg. kg-1.mouse-1.day-1 and standard drug 20mg of 5 Flurouracil kg-1.mouse-1.day-1 were administered orally through gavage for 14 days to group III, IV, V and VI respectively. Anti tumor effect of MPO was assessed by observing the changes with respect to body weight, packed cell volume, viable and non-viable tumor cell count, median survival time and percentage increase in life span (% ILS). Ingestion of 5 mg of MPO produced desirable changes in cancer induced mice and it was comparable with the EAC mice treated with 5FU 20 mg/kg body weight. In addition, MPO facilitated to reverse the changes by tumor growth proving its health benefits.
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The Investigation of the Relation between Emotional Intelligence and Organizational Commitment
The present study aims to identify the relationship between emotional intelligence and organizational commitment of high school teachers in Bushehr province this cross-sectional study using a questionnaire survey among secondary school teachers in the school year 2010-2011 was a Bushehr province. The study population of 1,753 secondary teachers out of Bushehr province which 156 (90 female and 66 male) of them classified as intermittent sampling with volume and Cochran were selected based on a formula. Emotional Intelligence questionnaire meets the standards of Meyer and Allen and Meyer Salve and organizational commitment. Emotional intelligence questionnaire reliability 0/81 organizational commitment questionnaire reliability 0/89, respectively and they both scale alpha of 0/7, so they both had a sufficient reliability of the questionnaire. To analyze the data, as SPSS and also test and analysis of variance and t-test for comparison of different uses and results indicated this was the only variable affecting the significance of differences between groups sex sample was different, this means that women have higher emotional intelligence and organizational commitment than men, and this difference was significant. The other significant differences in demographic variables between the groups.
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Relationship between Participative Management and Mental Health
Different management styles are in vogue in the management world and are practiced by educational managers to enhance individual and collective efficiency of employees Participative management is a practice that managers use as an attempt to satisfy employees and increase productivity. This review looks at the research on participative management and the effects on mental health of Bushehr have been a high school teacher. research methods, descriptive correlative The populations of this study consisting of all secondary school teachers in the province The school 2010-2011year and have been working as number 950 out of the total of 250 people were selected. Through participatory management information questionnaires reliability 0/85 mental health reliability 0/89 were collected. For data analysis, descriptive and inferential statistics were used The level of inferential statistics Pearson correlation coefficient and multiple regression analysis were used to analyze the data, The results showed that there is a significant positive relationship between participative management and mental health.
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