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Duloxetine, a medication with effects on both serotonin and noradrenaline transporter molecules, has recently been approved for the treatment of generalized anxiety disorder. Thus, the aim of the present study was to synthesis and formulates enteric coated pellets for delayed release and to characterise the physico-chemical property and dissolution. Duloxetin was prepared by photochemical reaction of n-bromo succinamide in carbon tetra chloride in the presence of catalytic amount of benzoyl peroxide. The prepared Duloxetine hydrochloride powder was then blended with mannitol and disodium hydrogen phosphate and sieved through 250 micron screen mesh to prepare dusting powder. It is then formulated as pellets which were seal coated by HPMC 5 cps. Further this seal coated pellets were enteric coated by using Eudragit L 30 D 55 (ammonio methacrylate copolymer dispersion), talc, triethyl citrate, titanium dioxide and purified water with the use of silversten stirrer (UK). The prepared formulations were characterized by scanning electron microscopy, differential scanning calorimeter, X-ray diffraction and Fourier transform infrared spectroscopy. Dissolution profile of the enteric coated pellets was compared with its recrystallized sample and pure sample. The samples were stored in stability chamber to investigate their physical stability. In stability test, the release profile of the pellets was almost unchanged as compared with the freshly prepared pellets stored at 40 0C and 75% relative humidity for 90 days. Hence these pellets can be formulated for giving Duloxetine hydrochloride as a delayed released formulation.

Technical and Vocational Education (TVE) play an important role in shaping human labor so can meet the job market in the industry. Ministry of Education (MOE) has identified the importance of PTV to ensure the country's aspiration to become a developed country by 2020 is achieved. The transformation PTV which are being implemented by the Ministry of Education should be supported by all parties involved. While transformation efforts to upgrade the vocational schools and vocational colleges restructuring subject vocational secondary schools implemented, the strategy of sustainable development in the PTV should be given attention accordingly. There are seven strategies of sustainable development that has been introduced by (UNEVOC) to be discussed in this paper to help mainstream the program TVE in the country. Seven strategies have been outlined by the International Center for Technical and Vocational Education and Training (UNEVOC) will be discussed, namely: (i) Support and the country's vision, (ii) Support to investigate the state police PTV, (iii) Guidelines for planning and implementation, (Iv) Capacity building and training programs, (v) Support the development of materials, resources and learning equipment, (vi) Relationships and partners in PTV, and (vii) monitoring, evaluation and research continues

People opinions and experience are very valuable information in decision making process. The necessary content of reviews should be extracted and analyzed properly. This information is useful for manufacturer and consumers. Sentiment analysis is used to analyze each opinionated phrase or word and determine the sentiment orientation. And finally it gives the summarized opinion of a document or sentence.

Conversion within quantities of same units and between quantities of different units is a thorny subject to students of Jasikan College of Education (Butterfield, Sutherland & Molyneux-Hodgson, 2000) and its treatment by tutors sometimes becomes very difficult such that most tutors resort to handling the subject theoretically/ abstractly. When this happens most students seemed not to comprehend the subject. In view of this, the DTML-Conversion model (i.e. D-Conversion model, T-Conversion model, M-Conversion model and the L-Conversion model) was designed. The DTML-Conversion Model is a model that has been designed by the researcher to make the teaching of conversion in measurement very easy to tutors and meaningful to students. The DTML-Conversion Model was tested on first year students of Jasikan College of Education. The researcher tested the DTML-Conversion model on 150 first year students in Jasikan College of Education by first teaching conversion using the traditional method which is the Conversion-factor for distance, time, mass and litre for a period of one month. A test was administered, collected and recorded, after which the DTML-Conversion model was introduced with similar test items. Comparison of the two test results showed that, students seemed to comprehend conversion in measurement with the DTML-Conversion model to the conversion-factor method.

The Expectation-Maximization (EM) algorithm is a parameter estimation method which performs to the general data frame of maximum-likelihood estimation, including some applications to data analysis and statistics. There is the work by Dempster, Laird and Rubin (1977) on the key features of defining the EM algorithm. Logistic mixtures, unlike normal mixtures, have not been studied for the EM algorithm. In this paper, we express the theorem about a relationship between the gradient of the log likelihood and the step in parameter space taken by the EM algorithm in their multivariate extension for the mixture logistic distribution (see Malik and Abraham (1973)). The literature on determination of the number of modes in logistic mixture models has focused primarily on univariate mixtures. In fact, there is a simple description of modality when one is mixing two univariate components. In particular, an analogue of the techniques such as the paper written by Robertson and Fryer (1969) allows to attain the results in the case of the convex combination of two item response functions (IRFs) for the unidimensional dichotomous 1-parameter to 4-parameter logistic (1PL to 4PL) item response theory (IRT) models.

Spelling is a way of representing the sounds of speech. In order to spell a word, you first say that word to yourself. Then you choose letters to represent the sounds you hear. Clearly, it is important to know how sounds and spellings match up. You are not aware of this process when you write familiar words because you have memorized their spellings. Writing these words is automatic. A good speller can write a great many words without thinking about which letters to use. But there are many times when you must choose the letters carefully; for example, when you write new words or words you have not used often. There are two reasons why you must make a choice. First, the same sound may be spelled in different ways as in meat, meet and mete. Second, nearly half the letters in the alphabet can stand for more than one sound! There are 39 English speech sounds but only 26 letters in the alphabet. Obviously, some letters must do extra work. This is particularly true of vowel letters.

This study investigates the relationship between human capital management and employees’ performance. For measuring variables three separated questionnaires were designed and after proving their validity and reliability, distributed among participants. The results of applying Spearman test show positive and meaningful correlations between human capital dimensions with employees’ performance. Also Chi Square test illustrates no relationship between employees’ demographic characteristics and their performance. In continue by Binomial test all variables’ levels were surveyed in which all of them apart from employees’ creativity. And finally the results of utilizing fuzzy TOPSIS technique human capital indices were ranked in which employees’ abilities for management, learning technical employees and employees’ abilities to associate were selected as the most important ones.

In the years after the revolution, the establishment of border markets, a new step in the direction of making more efficient border transactions. Despite the prominent role of these centers, the development of exchanges, regional, and economic prosperity of the region, performers plaza and along the border show that the balance of trade areas was negative, and often the activity of import that, should their role in the economic well-being influence, and on this basis to the market, investigated and evaluated, so that appropriate planning, it was based on. This study is based on a descriptive analysis and aimed to investigate the role and impact of border markets Parvizkhan in improving the economic situation of the inhabitants of the region, has been discussed. The population, including people working in the border area Feedback Pervez Khan, to the number 2320, which, according to Cochran formula, 300 people were selected as sample. In this research, data analysis, one-sample t-test was used. Results show that the mean responses provided by respondents, the impact of border markets, on the regional economy 3/447,from 5 is that if this average, to extend community, with 95 percent of the average responses people between 3/393 to 3/501 is, and because of this number (3/447), the number 3 (1 very low 2 low 3 middle) is larger, it can be concluded, the impact of border markets, the economy of the region, is almost too much. On the other hand, because Sig = 0, smaller than 0/05, this test is statistically significant. This in employment, income and drug trafficking, has led to improvements.

In the world, different rulers have adopted various ways in carrying out their political functions. The society sees its leaders as pace setters, but it is unfortunate that some of these leaders do not know that they are the role models to the younger generations. Instead of doing the right thing, they rule corruptly thereby sending wrong signals to those who care to be swayed by their political dance. The major aim of a leader should be to carry her citizens along 'thereby avoiding the use of force and eradicating corruption in its system of government. Hence the world needs leaders who are true to their calling in all sincerity thereby promoting a peaceful and corrupt free society.

The purpose of this paper is to determine the variances and significance of variances in capital values of properties in metropolitan Lagos of Nigeria resulting from anchoring and adjustment methods used by independent valuers in carrying out valuations within the scope of standard and non-standard anchoring paradigm. Valuation problems of ten properties were presented to 144 valuers in metropolitan Lagos to solve; but 104 (72.2%) participated in the experiment; and the One –sample t-test was used to test the variances. The significant P were all 0.00 for the ten properties; and this means that there are significant variances in estimates of property values determined by the valuers in the area of study. Crises in financial markets in Nigerian economy in the ending years of 2008 resulting from poor property valuation and unreliable values of collateral properties advised by independent valuers have heightened the need to find remedial measures to mitigate wide variances in the property values. Also, wide variances in capital values of real properties will result to clients losing confidence in values advised by valuation professionals.