Archives-J 

Cancer is a hyper proliferative disorder marked by metastasis into the vital organs of the body through invasion and angiogenesis. Biodegradable nanoparticles have been used frequently as anti-cancer drug delivery vehicles due to its splendid bioavailability, better encapsulation, and control release with less toxic properties. Various nanoparticulate systems, general synthesis and encapsulation process, control release and improvement of therapeutic value of nano-encapsulated cancer drugs are covered in this review. We have highlighted the impact of biodegradable polymer such as PLGA, PLA, chitosan, gelatin, polycaprolactone and poly-alkyl-cyanoacrylates in the formulation of nanoparticles for encapsulation of cancer drugs. Hence in the current review a detailed studied has been done for the delivering of cancer drugs effectively using biodegradable polymers.

This study assessed the health care services in relation to guardians level of satisfaction with childcare services at the Tamale Central (TCH) and Tamale West hospital (TWH), Ghana. The target populations of this study were guardians of sick children under five who visited the TCH and TWH. A total sample size of 100 respondents was used. 50 participants were each taken from the two Hospitals by using convenience sampling technique. Questionnaires was used for data collection and the data was analyzed using SPSS. A total of 41.2% of the patients were satisfied with the overall service received at the hospital. Guardians who were satisfied with the service significantly had a shorter waiting time than those who were not satisfied. In conclusion, mothers/guardians’ level of satisfaction with childcare are associated with four important dimensions namely; time spent at the hospital, relationship between health worker and parents, affordability of healthcare services and level of confidentiality that exist in the hospital. Long waiting time negatively affected satisfaction. If this is improved upon, it will lead to increased guardian satisfaction regarding the care rendered to their children.

One of the basic areas of the computer science is Data Structure. Sorting is an important issue in Data Structure which creates the sequence of the list of items. Although numbers of sorting algorithms are available, it is all the more necessary to select the best sorting algorithm. Therefore, sorting problem has attracted a great deal of research as sorting technique is very often used in a large variety of important applications so as to arrange the data in ascending or descending order. This paper presents a Both Ended Sorting Algorithm which is faster or better than the bubble sort& others algorithm. After having studied various sorting algorithms; I came to the conclusion that there is no such sorting algorithm which works on the basis of both end comparison right end as well as left end. The new algorithm so is then analysed, implemented & tested. The test results obtained are then presented and compared with the traditional Sorting Algorithm. Worst case complexity is also improved as a compare to bubble sort.

Three reliable, rapid and selective methods have been developed and validated for the determination of mebeverine hydrochloride and chlordiazepoxide in pharmaceutical dosage forms. The first method is first order derivative spectrophotometric method All variables affecting the reaction have been investigated and the conditions were optimized. The second method is based on separation of the cited drugs (mebeverine hydrochloride Rf =0.72 ± 0.02 and chlordiazepoxide Rf = 0.43 ± 0.04) followed by densitometric measurement of the intact drug spots at 220 nm by HPTLC. The separation was carried on silica gel plates using chloroform: methanol: ammonia (9.5: 0.5: 0.1, (v/v/v) as a mobile phase. The linearity range was 200-1200 ng/spot for mebeverine hydrochloride and 100-600 for chlordiazepoxide. The third method is accurate and sensitive HPLC method based on separation of mebeverine hydrochloride and chlordiazepoxide on a reversed phase C18 column, using a mobile phase of potassium dihydrogen phosphate buffer (0.05 M, pH 4.0 adjusted with 0.5% orthophosphoric acid)-methanol- water (30:50:20, v/v/v) and UV detection at 260 nm in an overall analysis time of about 5 min., based on peak area. The accuracy and precision of the methods were confirmed when the standard addition technique was applied. The validation was performed according to ICH guidelines. The results obtained by applying the proposed methods were statistically analyzed.

This study investigates the predicted effects of climatic factors during convenient intervals (in days) on cotton flower and boll production compared with daily observations. Also, covers the statistical relationship between climatic variables and aspects of cotton production and the effects of climatic factors prevailing prior to flowering or subsequent to boll setting on flower and boll production and retention in cotton. Further, cotton flower and boll production as affected by climatic factors and soil moisture status has been considered. Evaporation, sunshine duration, relative humidity, surface soil temperature at 1800 h, and maximum air temperature, are the important climatic factors that significantly affect flower and boll production. The least important variables were found to be surface soil temperature at 0600 h and minimum temperature. The five-day interval was found to be more adequately and sensibly related to yield parameters. Evaporation; minimum humidity and sunshine duration were the most effective climatic factors during preceding and succeeding periods on boll production and retention. There was a negative correlation between flower and boll production and either evaporation or sunshine duration, while that correlation with minimum relative humidity was positive. The soil moisture status showed low and insignificant correlation with flower and boll production. Higher minimum relative humidity, short period of sunshine duration, and low temperatures enhanced flower and boll formation.

We are very happy to announce that from 6th April 2015, Dr. M.J.Jijin has joined the team of Elixir Editorial Advisory Board. He will carry a special responsibility for dealing with manuscripts based on Extractions and Impactions. Dr. M.J.Jijin currently working as Dental Surgeon, C.H dental care, Malappuram (Dist), Kerala. The appointment of Dr. M.J.Jijin as member Editorial Advisory Board strengthens the links and will make it easier for prospective authors to establish contact with the journal. 

We are very happy to announce that from 11th September 2013, Dr.C.Surendra Dilip has joined the team of Elixir Editorial Advisory Board. He will carry a special responsibility for dealing with manuscripts based on Chemistry. Dr.C.Surendra Dilip is currently working as Assistant Professor, Department of Chemistry, Anna University, BIT Campus, Tiruchirappalli. The appointment of Dr.C.Surendra Dilip as member Editorial Advisory Board strengthens the links and will make it easier for prospective authors to establish contact with the journal. Please send any expressions of interest to elixirpublishers@gmail.com. Sincerely Editor-in-Chief

The purpose of conservation tillage is to reduce the intensity of tillage operations and increase the amount of crop residue on soil surface. One of the characteristics of soil in arid and semi-arid areas is the lack of organic matter. Crop residue management is one of the soil fertility and improvement methods that is achieved by conservation tillage. Compared to residue burning, maintaining crop residue on or near the soil surface under no-tillage and minimum tillage methods will improve the organic carbon, Soil structure and activity of micro-organisms. Soil organic matter in a temperate and humid area increased by 16% and in a temperate and dry area increased by 10% than conventional tillage systems.

Load balancing using clustering can increase network scalability. This paper attempting to apply efficient techniques of load, energy and security such that network life can be increased with security and also its reliability. Continuous aggregation is required in sensor applications to obtain the temporal variation information of aggregates. It helps the users to understand how the environment changes over time and track real time measurements for trend analysis. Existing secure aggregation schemes conduct one individual verification for each aggregation result. Due to the high frequency and the long period of a continuous aggregation in every epoch, the false temporal variation pattern would incur a great communication cost. In this paper, we propose a clustering technique which will balance the load among the cluster by using some backup nodes. The backup high energy and high processing power nodes replace the cluster head after the cluster reaches to its threshold limit. This approach will increase the network lifetime and will provide high throughput and in the continuous aggregation, the attacker could manipulate a series of aggregation results through compromised nodes to fabricate false temporal variation patterns of the aggregates .We detect and verify a false temporal variations pattern by checking only a small part of aggregation results to reduces a verification cost. A sampling based approach is used to check the aggregation results and we also proposed a security mechanisms to protect the sampling process.

We report the case of Mr. FL aged 60 , former smoking with 15 packs / year weaned ago 30 years, no particular medical history who underwent total cystoprostatectomy bladder tumor infiltrating the muscle 14 years ago enterocystoplasty with it .