Archives-December  

The purpose of the present study was to formulate and evaluate once daily sustained release matrix tablets of carvidolol phosphate. Carvedilol Phosphate is a nonselective beta blocker indicated in the treatment of mild to severe congestive heart failure Various formulations of sustained release tablets of Carvidolol phosphate were developed using various polymers Guargum, SCMC, HPMC100M in different concentrations by direct compression method. Observations of all formulations for physical characterization had shown that, all of them comply with the specifications of official pharmacopoeias and a standards reference. Results of in-vitro release profile indicated that formulation(F9) was the most promising formulation as the extent of drug release from this formulation was high(100.75 %) as compared to other formulations.From the above results and discussion it is concluded that formulation of sustain release tablets of carvidolol phosphate containing Guar gum (33.33%) ,formulation F9 can be taken as an ideal for optimized formulation of sustain release tablets for 24 hours release as it fulfills all the requirements for sustained release tablets.

LAM or Pulmonary lymphangioleiomyomatosis is an uncommon disease that predominantly touches women in their reproductive years. The disease is usually discovered in an incidentally way and detected in a high resolution thoracic CT scan. Its progress could lead to respiratory failure. This article is about a patient in our ward that got a chest CT scan in which the final diagnosis was a lymphangioleiomyomatosis in a case of tuberous sclerosis complex.

In this study an extended geophysical survey using gravity and high angle refracted seismic methods with recorded earthquake has been carried out in Kerman province in southeast of Iran. The purpose of the applied geophysical surveys was to provide information on crustal structure and lithospheric thickness. The purpose of this research is focused on determination of Moho depth and for this reason several profiles for both methods were performed and by use of topography and gravity data with a reasonable combination with high angle refracted seismic data and earthquake record, the crustal and lithospheric thickness of Kerman province was calculated. Oldenburg- Parker algorithm was the base of gravity survey of the present work but by use of Matlab programming environment and generated C Sharp computer codes was optimized, improve and then executed. The key factor of this study was generated computer code, which named as “MOHO R.A.T 1.01”. For seismic data, a least-squares analysis of the travel-time data was made and the uncertainties were taking in to account. Finally, depth calculations for the velocity discontinuities and gravity anomaly contour maps were made. The comprehensive comparison between the obtained results and other studies on the selected area showed good agreement, which verified the ability of produced code.

The dairy waste, whey protein was modified by reaction with phthalic anhydride. The phthalated whey protein (PWP) and its mixture with bagasse, and corn cob were prepared. Such mixtures were used for removal of heavy metals (Pb, Cr, Cd, Ni, Cu, Fe and Zn) by batch adsorption method from electroplating industrial wastewater. In such a batch adsorption process the above adsorbent materials were used as bed and the parameters; effect of contact time, dosage, a temperature and pH were evaluated. The finding of this investigation reveals that the product natural adsorbents have excellent capacity to remove heavy metals from industrial effluents.

The Bibiani government hospital over the years has recorded high cases of hypertension, anaemia and muscoskeletal pain. Analysis of data acquired from the Bibiani government hospital showed that, cases of hypertension increased in the years 2015, 2016 and 2017. Similar trend was observed for the other diseases. Using the World Health Organisation standard age categorisation to know the age distribution of the reported cases, of the total number of cases reported for the respective diseases, the adult age group recorded higher percentages. The infant age group, recorded an abnormal percentage for anaemia cases. However, the high percentages recorded for the adult and infant age category needs to be investigated. The groundwater quality parameters were compared with the World Health Organisation WHO and Burae of Indian Standard (BIS). Essential trace elements namely Iron, Zinc, Copper and Magnesium were found to be deficient in the drinking water of the inhabitants of Bibiani. The deficiency of the above-mentioned trace elements can be assessed as a possible source to health problems in Bibiani.

Human health risk assessment on intake of fish contaminated with organochlorine contaminants has been investigated in seven fish species from Lake Bosomtwi and Weija Lake in Ghana. The species studied were Tilapia busumana, Hemiscrimis faciatus, Sarotherodon galileu from Lake Bosomtwi and Tilapia zilli, Tilapia nile, Tilapia galilaea and Clarius gariepinus from Weija Lake. Risk assessment was carried out by estimating daily exposure as well as carcinogenic and non-carcinogenic implications on consumption of the studied fishes. Estimated daily exposures to OCs on dietary intake of fish were in the range of 0.002 µg/kg to 0.176 µg/kg and 0.001 µg/kg to 0.0892 µg/kg for children and adults respectively. Consumption of Clarias gariepinus indicated the highest health risk to organochlorine exposure. Children were exposed to more OCs than adults on consumption of the same quantity of contaminated fish. Estimated daily exposures however, fell below USEPA reference doses. Cancer hazard analysis showed that more than one in a million of the consuming population could get cancer on eating Clarias gariepinus due to hexachlorocyclohexanes (HCHs) contamination. However, consumption of the investigated fish from Lake Bosomtwi presents no risk of cancer. Organochlorines were extracted from samples by sonicating on an ultrasonic bath with hexane/acetone solvent system and organochlorine contaminants were determined using capillary gas chromatograph equipped with electron capture detector.

This paper presents comparative study and simulation results for different Hybrid Multilevel Inverter configurations. This paper covers hybrid multilevel inverters such as cascaded multilevel inverter with high voltage low-frequency pulse width-modulation (PWM) and low voltage high frequency pulse width-modulation (PWM) and series connected half-bridge modules hybrid multilevel inverters. Here the operating principle of each topology is discussed with a review of the relevant modulation method focusing mainly on total harmonic distortion (THD). Such multilevel inverters achieve higher power quality with a given switch count when compared to traditional multilevel inverters. The purpose of the circuits presented here is to minimize the reverse voltage stress that affects the power switches and decrease the harmonic distortion of the voltage applied to the load.

Hydrogen peroxide induce the oxidative stress on the cells. The free oxygen radicle denature the protein by oxidizing the thiole group of protein having cysteine or methionine amino acid that donate proton to free oxygen species thus creating un even di sulphide bonds in protein. Besides H2O2 reduces protein synthesis in various ways with increasing concentration of infusion as well as time. Glutathione which is a natural anti oxidant in cell tries to reduce the oxidative stress in the cell. Glutathione is a tri peptide of glutamate, cysteine and glycine produced by cells. Glutathione prevent oxidation which protect cell and its components from free radicles, reactive oxygen species and peroxides. The ratio of oxidised and reduced glutathione within a cell is indicator of state of oxidative stress on the cell. Thiole group of glutathione donates proton to reduce the oxidative stress on the cell. In an in vitro experiment, liver cell of goat were cultured in M199 media and production of glutathione per milligram of protein with respect to different concentration of hydrogen peroxide as well as different time, glutathione production and protein synthesis was measured by standard method. The production of glutathione per milligram of protein increases with increase in concentration of H2O2 and time.

The paper proposed the application of a new four-dimensional hyper chaotic map based on the Lorenz chaotic system to realize chaotic encryption for improved security. Hyper chaotic systems are more complex and difficult to predict. An image encryption algorithm is designed by utilizing the basic operations like permutation, confusion and diffusion. The combination of the user defined 256 bits secret key and the plain image are used as initial conditions for the 4D hyper-chaotic system to generate the key matrix. Several test images are used for inspecting the validity of the proposed work. The security analyses and computer simulations on the basis of key space analysis, statistical analysis, histogram analysis, information entropy analysis, correlation analysis and differential analysis is done. The NPCR and UACI values of encrypted images are also calculated. The result shows that a single bit change in the pixel value of the input plain images will cause a significant changed in the ciphered images. Total key space for the proposed method is 2256, which is good enough to protect the encrypted image against brute-force attack.

Hydatid disease is a parasitic infestation that is a public health problem in many countries of traditional livestock breeding where it is endemic. Frequently encountered localizations are of hepatic and pulmonary sites, whereas cerebral localization is rare. CT is the test of choice for the diagnosis and postoperative follow-up of cerebral hydatid cyst. MRI is useful for atypical or complicated forms and allows for adequate surgical planning. We report three observations, two of which have an atypical appearance in imaging.