Intra-Muscular Platelet Rich Plasma Increases Platelet Derived Growth Factor and Regenerates Exercise-Induced Muscle Damage
Platelets rich plasma (PRP) is reported to facilitate muscle regeneration both in vitro and animal studies. The aim of the study was to evaluate the intramuscular of PRP on growth factors and the regeneration of exercise induced muscle damaged (EIMD).Volunteers were assigned to a control (n=6) or PRP (n=6), and performed exhaustive exercise with one repetition maximum (1RM-80%) maximal voluntary contraction of the elbow. The arms were treated with saline or PRP post-24h exercise and blood samples were obtained in the morning to establish a baseline value and also 1-4 days post-exercise. The baseline levels of plasma insulin-like growth factor 1(IGF-1), insulin-like growth factor-binding protein 3 (IGFBP-3), vascular endothelial growth factor (VEGF) were different whilst growth hormone (GH) and platelet-derived growth factor (PDGF-BB) levels were similar in both groups. However, 24 h following exercise increased levels of IGF-1, GH and IGFBP-3 in control were observed. PRP up-regulated PDGF-BB and VEDF, it also inhibited GH, IGF-1 and IGFBP-3 levels post-exercise.
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