Pharmacy

In recent studies, parental product remains the most crucial means for administering of the therapeutic agent with proteins and peptide due to its poor bioavailability. Therapeutic proteins are becoming more important in an ever-increasing part of the healthcare system. The structural and therapeutic property of these molecules makes them more dependable on drug delivery technology so that they can achieve their maximum effectiveness. However, formulating proteins such that they maintain their stability and that they are delivered within their efficacious and safe target doses remains a challenge. The protein delivery systems reviewed in this article have been divided in to three groups, the oral, intestinal and colonic deliver

This study was designed to investigate the quality of Victoria 1500 and 2000 capsules a herbal medication that contain ginseng (major components Rg1&Rb1), royal jelly (marker component is 10-hydroxydec-2-enoic acid (10-HDA)) and yohimbine. The study include determination of major components content, long term stability, determination of elements , studying the microbiological contamination, detection of pesticides residues and mycotoxins. The drugs were stored under different simulated climatic conditions. The reaction rate constant (K), the half-life (t1/2) and the activation energies were calculated for ginsenosides Rg1 &Rb1. The activation energies were found to be 10.99 and 10.2( k.cal.mol-1 ) for Rg1 &Rb1respectively. The % content of Rg1, Rb1 and 10-HDA of Victoria1500 &2000 capsules after six months storage were found at the lower specifications limit (80-120% of stated amount). For yohimbine were found within allowable limit(90-110%). Studies on the elemental composition confirmed absence of toxic heavy metals. The capsules were found to be free from Microbiological contamination and any pesticide residues. The mycotoxins content were found to be within the allowable limits(800-4300ng/kg). Victoria 1500&2000 capsules were found to comply with the given specifications up to six months storage, thereafter, the samples showed physical &chemical instability with a decrease in Rg1,Rb1 and 10-HDA contents but without effect on yohimbine content.

Calculated indices are now emerging as clinically useful tools for the preliminary diagnosis for a variety of disorders/diseases. Such indices are derived from a measured analyte or set of analytes and they will then be used as tools to monitor/evaluate the preliminary clinical condition associated with a particular organ such as liver, kidney or respiratory related problems. Among such calculated parameters, eGFR and FENa for renal, liver enzyme ratios, FIB-4 and APRI for liver and anion gap for acid base disorders have been extensively used. This review article highlights the recent research findings in the use of such calculated parameters for clinical use, and its merits and demerits in providing awareness to clinicians about its significance and use in clinical practice.

The aim of the present study is to formulate and evaluate Captopril micro-encapsules. Microspheres and micropellets of captopril prepared with different polymers through the techniques of microencapsulation were found to have a good spherical shape, and were non-aggregated exhibiting good flow properties. In addition, all the formulations prepared, showed a good drug incorporation efficiency and an extended release of the drug, thereby enhancing the duration of action. The different techniques used in the preparation such as, emulsion-phase separation, solvent-evaporation and ionotropic- gelation techniques were found to be simple and reproducible. All the polymers used viz, chitosan, ethyl cellulose, sodium alginate and HPMC were economic, easily available and biocompatible. And hence, the industrial applicability of the methods would be simple and rapid, provided the work being extended to in-vivo studies. It is obvious from the above work that, the study has engineered a drug delivery profile in which the drug release is controlled to a great extend and that the formulations in therapy can minimize untoward side effects, thus improving patient compliance.

The purpose of the present study was to formulate and evaluate once daily sustained release matrix tablets of carvidolol phosphate. Carvedilol Phosphate is a nonselective beta blocker indicated in the treatment of mild to severe congestive heart failure Various formulations of sustained release tablets of Carvidolol phosphate were developed using various polymers Guargum, SCMC, HPMC100M in different concentrations by direct compression method. Observations of all formulations for physical characterization had shown that, all of them comply with the specifications of official pharmacopoeias and a standards reference. Results of in-vitro release profile indicated that formulation(F9) was the most promising formulation as the extent of drug release from this formulation was high(100.75 %) as compared to other formulations.From the above results and discussion it is concluded that formulation of sustain release tablets of carvidolol phosphate containing Guar gum (33.33%) ,formulation F9 can be taken as an ideal for optimized formulation of sustain release tablets for 24 hours release as it fulfills all the requirements for sustained release tablets.

The first closed bilayer phospholipid system called Liposomes, was described in 1964 and soon was proposed as drug delivery system. Liposome was found by Alec Bangham of Babraham Institute in Cambridge, England in 1965. In 1965s, it was well recognized that microscopic lipid vesicles, known as liposomes, could be utilized to encapsulate drugs and dyes for the purpose of systemic administration and drug targeting.Liposomes have been widely investigated since 1970 as drug carriers for improving the delivery of therapeutic agents to specific sites in the body. In 1990; drugs with liposome and Amphotericin B were approved by Ireland. In 1995 America F.D.A approved liposor doxodubicin. The liposome a microscopic spherical particle formed by a lipid bilayer enclosing an aqueous compartment.An artificial microscopic vesicle consisting of an aqueous core enclosed in one or more phospholipid layers, used to convey vaccines, drugs, enzymes, or other substances to target cells or organs. This review discusses the mechanism of liposome formation, structural components of liposome, classification, preparation method, pharmacokinetics,targeting, advantages, disadvantages, limitation, factors affecting the formation, characterization, potential applications of liposomes in drug delivery with examples of formulations approved for clinical use and products in clinical trials.

Ulcerative colitis is a chronic inflammatory disease of the rectum and colon. Results from many studies in people and animals of intestinal inflammation suggest that ulcerative colitis results from environmental factors triggering a loss of tolerance for normal intestinal flora in genetically susceptible individuals. Ulcerative colitis (UC) is an inflammatory chronic disease primarily affecting the colonic mucosa; the extent and severity of colon involvement are variable. In its most limited form it may be restricted to the distal rectum, while in its most extended form the entire colon is involved. UC belongs to the inflammatory bowel diseases (IBD), which is a general term for a group of chronic inflammatory disorders of unknown etiology involving the gastrointestinal tract. UC is usually associated with recurrent attacks with complete remission of symptoms in the interim.. The leading initial symptom of UC is diarrhea with blood and mucus, sometimes with pain. Fever and weight loss are less frequent. Extra intestinal symptoms can be an initial manifestation or can occur later in the course of the disease. Eighty percent of the patients have only proctitis or proctosigmoiditis, and only 20% have extensive colitis. However, in about 50% of patients with initial proctosigmoiditis, proximal extension occurs later, and in some patients the opposite takes place. Depending of the stage of the disease, endoscopy reveals reddening of the mucosa, increased vulnerability, mucosal bleeding, irregular ulcers, pseudopolyps, granularity, and loss of vascular architecture. Several drugs interacting with various points along the immune and inflammatory cascades are currently available for the treatment of UC. Corticosteroids, aminosalicylates, immunomodulators are the mainstay of medical treatment.

Antimicrobial control programs are widely used to decrease antibiotic utilization, but effects on antimicrobial resistance and outcomes for patients remain controversial. The purpose of this study was to determine the impact of rotation of antibiotic classes used as empirical surgical prophylaxis on the emergence of bacterial resistance organisms and antibiotics drug use when compared with non-rotation period. Three core, broad spectrum agents (Cephalosporins, beta-lactam-inhibitors, and fluoroquinolones) were selected for inclusion in the quaternary rotation for 21 months, based on prior 8 months baseline data from GIT and urology surgical wards in Ibn Sina hospital. Intensive surveillance done for patients admitted to the selected settings. 1681 surveillance samples obtained from 2359 eligible inpatients admitted to hospital from Jan 2008 to May 2010. A significant reduction in the percentage of positive growth had been observed with antibiotic rotation for both wards from 65% and 49% in baseline to 59% and 33% in rotation (1) and 25% and 33% in rotation (2) in GIT and urology ward respectively (p? 0.0001). As general there was a divergent effect of the antimicrobial rotation on the prevalence of resistance among G+ve and G-ve bacteria. We concluded that antimicrobial drug use in surgical departments could be optimized after implementation of antimicrobial cycling policy, and associated in reduction in the incidence of infectious mortality and morbidity but stabilize antibiotic resistance, without significant reduction.

Pharmacovigilance is an important and integral part of clinical research. Pharmacovigilance is defined as the pharmacological science relating to the detection, assessment, understanding and prevention of adverse effects, particularly long term and short term adverse effects of medicines. Pharmacovigilance will certainly help identifying risks and risk factors in the shortest possible time so that harm can be avoided or minimised. Pharmacovigilance is the science and activities relating to detection, assessment, understanding and prevention of adverse effects or any other possible medicine related problem. Today its importance cannot be sidelined at all, given the number of new medicines being introduced in the market.

Shampoos are products which remove surface grease and dirt from the hair shaft and scalp. The cleansing or detergent action of a shampoo along with anti microbial and anti-lice activity is beneficial for the consumers. Now a days herbal shampoo shows better activity, safer and popular when compared to the synthetic shampoos. We made an attempt to formulate a poly herbal shampoo by using neem leaf, thulasi leaf, mehandi leaf and gooseberry fruit along with synthetic compounds. The prepared formulations were evaluated for its physicochemical properties, anti-microbial and anti-lice activity; which was compared with the marketed products. The herbal shampoos showed better effects than marketed synthetic shampoo and also with lesser side effects.