Organic Chemistry

A series containing fourteen substituted styryl 5-methyl-2-furyl ketones [2E- 1(5-methyl-2-furyl)-3-(substituted phenyl)-2-propen-1-ones] were synthesized by Crossed-Aldol condensation between2-acetyl-5-methylfuron and various substituted benzaldehydes. The synthesized ketones were characterized by their physical constants and spectral data. The group frequencies of infrared absorption (cm-1) of ?COs-cis and s-trans, ?CHout of plane and in-plane, ?CH=CH out of plane, ?>C=C

The electrochemical polarographic analysis of complex of Re (II) complex with the ligand 1-{3-[2-Amino-5-(5-hydroxy-5H-imidazol-4-ylmethanesulfonyl)-benzyloxy]-4H-pyrazol-4-yl}-ethanone were analyzed and it found that ligand forms 1:2 complex with Re(II) in between pH of alkaline range between 7.4-8.6. The logarithm value of stability constant of 1:2 metalis 14.9and the entropy and free energy observed at -78.69 and -43.48 respectively.

The repeated column chromatography of the methanol extract leads to the isolation of compound (1), which was identified as 7, 8-Dihydroxy-2H-chromen-2-one (Daphnetin) for the first time from this species. The structure of the compound was elucidated on the basis of 1H, 13C, MS etc spectral techniques. HPLC analysis method was developed for the detection and confirmation of daphnetin in the methanol extract of Daphne oleoides, which clearly determined its presence in the extract (Chromatographic Finger print) after the calibration with isolated Daphnetin. Keywords: Coumarins, Daphne oleoides, Thymelaceae, HPLC, Daphnetin.

The objective of the present work was to synthesize co polymer hydrogel composed of (PAAc) and (PAAc / Pectin) which are very sensitive to environmental stimulus, this feature is important for their application in biomedical applications, due to its unique Properties which can resemble human living organs, Wound dressing, drug delivery systems. Gamma radiation induce synthesis and modification of monomer to polymer hydrogel was studied. The effect of different parameter onto preparation of smart hydrogel such as monomer concentration, radiation dose on to swelling percent of the prepared copolymer hydrogel have been studied, gel fraction have been studied as a function of swelling ratio. Structure characterization of the prepared copolymer hydrogel have been investigated using fourier transform infrared (FTIR) spectroscopy, The morphological structure using X–ray diffraction analysis and scanning electron microscopy (SEM) have been studied. The swelling properties of the prepared copolymers have been studied at different time and pH. It was found that the swelling percent increases as the time increase and increases as pH increase and the maximum swelling occurs at pH 6 with the value of 19000 % for (PAAc) hydrogel and 10000% for (PAAc/pectin) hydrogels after 24 h. Drug loading measurements using ciprofloxacin drug at pH7 for (PAAc) hydrogel after 24 h and at pH11 for (PAAc/pectin) hydrogels. Studies of drug releasing of ciprofloxacin as drug model have been investigated, at different time and pH and it was found that the drug release incases as pH increase and the maximum release occurs at pH4 for (PAAc) and pH ( 3 , 8) for (PAAc/pectin) hydrogels, the antimicrobial activity of the synthesized co polymeric hydrogel under study was evaluated based on the diameters of clear zone surrounding the polymeric substance ( disk diffusion test ) this proved that polymeric hydrogel can be used as antibacterial agent.

The reaction of 3-Methyl-1-phenyl- 1H-pyrazol -5-amine(1) with 3-(5-Arylfuran-2-yl)-1-arylprop-2-en-1-one(2a-l), formed a novel heterocyclic compounds, 6-(5-Arylfuran-2-yl)-3-methyl-1-phenyl-4-(4-substituedphenyl)-1H-pyrazolo[3,4-b]pyridine 3(a-l). The structures of all the compounds series (3a-l) were characterized analytically. The compounds were also monitored for anti microbial activity.

Synthesis of new series of 3-[4-(1-acetyl-5-(substitutedphenyl)-4,5-dihydro-pyrazol-3-yl)phenyl]-6,8-dibromo-2-methylquinazolin-4-one has been achieved by the refluxation of 6,8-dibromo-3-{4-[5-(substitutedphenyl)-4,5-dihydro-pyrazol-3-yl]phenyl}-2-methylquinazolin-4-one with Glycial acetic acid for three hours. The intermediate have been synthesized by refluxation of 6,8-dibromo-3-{4-[3-(substitutedphenyl)prop-2-enoyl]phenyl}-2-methylquinazolin-4-one (0.01M) and 99% hydrazine hydrate (0.015M) by using ethanol (50ml) as a solvent with various aldehydes. The chemical structures of synthesized acetyl pyrazoline derivatives were characterized by their physical constants and spectral data. The new acetyl pyrazoline derivatives were screened for their antimicrobial activities against several bacterial and fungal species.

The spectrophotometric characteristics of the solid charge-transfer molecular complexes (CT) formed in the reaction of the electron donor 5-amino-1-methyl-3-phenypyrazole (AMPP) with the ?-acceptors tetracyanoethylene (TCNE) and 7,7,8,8-tetracyanoquinodimethane (TCNQ) and ?-acceptor iodine have been studied in chloroform at 25 0C. These were investigated through electronic and infrared spectra as well as elemental analysis. The results show that the formed solid CT- complexes have the formulas [(AMPP)(TCNE)], [(AMPP)(TCNQ)] and [(AMPP) I]+ I3- in full agreement with the known reaction stoichiometry in solution as well as the elemental measurements. The formation constant kCT, molar extinction coefficient ?CT, free energy change ?G0 and ECT energy have been calculated for the CT- complexes [(AMPP)(TCNE)], [(AMPP)(TCNQ)] and [(AMPP) I]+I-3.

Sudanese petrodiesel samples (S1, S2, S3 &S4) were collected from Khartoum refinery in Sudan. Samples were subjected to physicochemical investigation according to the American Society for Testing and Materials (ASTM) Tests include: density, kinematic viscosity, flash point, cloud point, colour, ash content, water content, sulfur content, carbon residue, copper strip corrosion, distillation and calculated cetane number. Results revealed that the physicochemical properties of petrodiesel samples were within the limits assigned by ASTM and Khartoum refinery except the water content for sample S1 was found to be 0.052% wlw. The cetane number was found to be 56.14, 54.72, 57.89 and 56.9 for S1, S2,S3 and S4 respectively, these values were found within recommended values to be used as fuels for diesel engines.

Series of compounds containing s-triazine derivatives were synthesized. The synthetic strategy utilizes cyanuric chloride as a starting material to obtain the several Schiff’s base A(1-5), azetidinone B(1-5) and thiazolidinone C(1-5) viz. condensations and cyclizations. All newly synthesized compounds have been characterized by physical processes (melting points, Thin layer chromatography, elemental analysis, IR and NMR spectra) and have been tested for their antimicrobial activity against gram (+)ve and gram (-)ve bacteria and also on different stains of fungi in which some of these derivatives exhibited potential antibacterial and antifungal activity.

Carawey is biennial plant. It is a widely used and incredibly useful plant. The seeds are used for culinary purposes and medicinal treatment. It’s seeds oil was extracted by cold extraction method used two solvents, n-hexane and petroleum ether. Extracts has been investigated by Gas Chromatography Mass Spectrometry (GC/MS) technique. Total of 45 compounds were detected for n-hexane extract and 62 compounds likewise for petroleum ether. The two solvent extracts showed a chemical composition correlation. The most abundant compounds detected are hexadecanoic acid; Estragole; 9,12- octadecandienoic acid ; 9-octadecanoic acid; Stearatric acid, D-Limonene, octadecanal, Eicosanoic acid, 11-Eicosanoic acid, dodec-9-ynyl Cyclohexanecarboxylicacid, 7-hexadecanoic acid, 9- octandecanone, 10- nonadecanone and anethole . Besides there are some new compounds that have not been previously reported.