Archives-May 2017

Regulatory requirements for various countries of world vary from each other. Therefore, it is challenging for the companies to develop a single drug which can simultaneously submitted in all countries for approval. Africa is the second fastest growing pharmaceutical market in the world and is driven by a small number of countries like south-Africa, Nigeria, Ghana, East-Africa, North Africa. During the past decade, the African continent has been home to some of the fastest-growing economies in the world, creating a large window of opportunity for the development of the pharmaceutical sector. Africa’s pharmaceutical sector was expected to reach about 30 billion US Dollars by 2016. The main objective of this study is to discuss about the various parameters and requirements for Registration of externally developed pharmaceutical products in North Africa for Approval. Pre-Requisite knowledge of country specific Guidelines and norms is very important to analyse the similarities and differences between the regulatory requirements of different countries. The Pharmaceutical Market in Africa is growing fast at a Compound annual growth rate (CAGR) of 10.6%. The value of Africa’s pharmaceutical industry jumped to $20.8 billion in 2013 from just $4.7 billion a decade earlier. That growth is continuing at a rapid pace: the market will be worth $40 billion to $65 billion by 2020. The purpose of this study is to focus on the key assessment parameters required for developing a pharmaceutical product so that it can be simultaneously registered in numerous African countries for approval.

Traditionally, educators have perceived television as not particularly beneficial to literacy development. Concerns were fueled by findings suggesting that with the introduction of television people spend less time reading books and reading scores decline. However, as the society is striving to make adjustments to the decline in literacy skills and new ways of learning and teaching are being explored, educators are becoming interested in exploring the educational potential of television and video for teaching basic literacy skills such as reading, writing, and math. The interest in television as an educational medium has increased for several reasons. The research literature suggests that the content of television can have four broad types of effects on children. They include behavior, attitudes, beliefs and values, knowledge, and cognitive skills. Many children's television series are educational, ranging from dedicated learning programs to those that indirectly teach the viewers. Some series are written to have a specific moral behind every episode, often explained at the end by the character that learned the lesson. Some television programs are designed with primarily educational purposes in mind, although they might rely heavily on entertainment to communicate their educational messages. In children's programming, edutainment becomes fun and interesting for the child but can still be educational.

In this paper, light is shed on the Special Relativity hidden conflicts. The first part will point out some of the Special Relativity self-contradictions in relation to its main outcomes; namely the time dilation, length contraction, relativistic velocity addition, relativistic Doppler shift, and the energy-mass equivalence The second part reveals the reasons beyond the Special Relativity inconsistencies, by demonstrating its mathematical formulation misconceptions, and identifying various contradictions in Einstein’s 1905 derivation of the Special Relativity equations.

With growing evidence regarding the association between oral health and respiratory disease, oral physician responsibility to provide top quality care is mandatory. By staying up to-date and using research available, oral physicians will be able to have the knowledge and skills to carry out proper assessment of patient, management, and prevention of the disease. Through this knowledge, the oral physicians will be able to educate patients regarding specific risk factors responsible for developing respiratory diseases and their prevention to avoid further complications. Besides, it will help to identify and manage those patients with associated problems. Oral physician should stay update with current research available, in order to educate the public and patients regarding the significance of good oral health.

Abacavir (ABC) {(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl] cyclopent-2-en-1-yl} methanol, is an antiretroviral medication which is used to prevent and treat HIV/AIDS. It belongs from nucleoside analog reverse transcriptase inhibitor (NRTI) a sub class of RTIs, which interrupt the virus to make copy of it. In this paper we reported the results of a systematic experimental IR and Raman study of Avacavir. Additionally the equilibrium geometry, harmonic vibrational frequency Raman and IR intensities were calculated using density function theory. Finally complete vibrational assignment of Abacavir is given for the observed Raman and Infrared spectra. The experimental and theoretical results are found to be in excellent agreement with each other. We believe that the results obtained herein will prove to be an excellent starting point for studying the detailed potential surface of the molecule which is needed to understand the drug receptor interactions.

The purpose of this study was to evaluate and compare the watercourse land use of pasture, rainfed and abandoned rainfed which conducted in Bab Karafs watershed (Sarduyeh) in Jiroft County using the artificial rainfall simulator device. In this study three land uses with constant soil type and lithology have been considered and also, rainfall intensities have been created by using rainfall simulator device and in two intensities of 46 mm/hour and 88 mm/hour, and as well as considering the slopes of 5 percent and 15 percent, according to the three repeats in 36 stages of sampling. Also, from adjacent parts of the rainfall simulator device and from 0-20 cm depth of soil, the soil samples were taken for analysis in a soil laboratory. The results showed that the land use changes indicate dramatic impacts on watercourse and erosion amounts in different slopes; so that the maximum amount of watercourse is carried out in the abandoned rainfed use and slope of 15%. The minimum amount of watercourse is carried out in the rainfed use and slope of 5%.

In this study three land uses with constant soil type and lithology have been considered and also, rainfall intensities have been created by using rainfall simulator device and in two intensities of 46 mm/hour and 88 mm/hour, and as well as considering the slopes of 5 percent and 15 percent, according to the three repeats in 36 stages of sampling. Also, from adjacent parts of the rainfall simulator device and from 0-20 cm depth of soil, the soil samples were taken for analysis in a soil laboratory. The results showed that the land use changes indicate dramatic impacts on soil sedimentation amount in various intensities of rainfall and different slopes; so that the highest amount of sedimentation is carried out in the abandoned rainfed use and intensity of rainfall of 88 mm/hour and slope of 15%.

This paper is built upon studies of defining an aesthetic philosophy and criteria of Timeless architecture, and using it to enhance building effect on users. After an argument was made for the justification of the concepts manifested for a timeless architectural aesthetic over the continuation of the current paradigm. As principles of a timeless aesthetic architecture are established: that timelessness represents a practical philosophy, that timelessness serves as the concept generator in the design process, and that timeless architecture is universally specific to the constraints of its concepts and style. three case studies are thereby examined in relation to these principles as well as more qualitative and quantitative evaluation factors, and criteria for built environment. The objective hereby is to analyze the selected buildings [to determine presence of timelessness quality. The results is evaluated according to the table of analysis developed in the Comprehensive Theoretical Foundation that resulted in the set of criteria for timeless buildings. Thus, the buildings are subjected in a comparative analysis to the checklist produced in the study to prove whether its timelessness complies with the study or not.

In recent years, we have witnessed a dramatic popularity of online social networking services, in which millions of people publicly communicate for a kind of mutual friendship relations. Social network research is one of the fastest growing academic areas as it is continuously expanding within our society. One key element of this field of research is social network visualization, which refers to the use of sociogram / illustrative diagrams of the joins that connect various actors in social networks. Visualization of social networks has a rich history, particularly within the social science since at least the 1930s. The use of graphical representations is one of the main defining properties of social networks. Researchers make use of pictorial images of social networks in order to communicate and understand the content and patterns within social networks. However, visual diagrams of social networks often suffer from a range of problems, the most common of which being the high density of edges and complex structures in large networks, providing sociograms that often appear as unclear set of nodes and edges. In this paper, we have made every possible effort to remove the fear from mind of people that understanding networks is a difficult process as it is difficult to visualize, navigate, and find patterns in networks. For this, we begin by defining what constitutes a social network site and then present our introduction of basic concepts of social networks, social network sites and then discussed about visualization needs and problems, benefits of using data visualization, implementations of visualization available over time.

The objective of this study was to do a comparative study of Follicular and letual phase of inhibins, estrogen, progesterone, LH and FSH. For women in both phases, levels of inhibin A, inhibin B, estradiol and progesterone decreased after the removal of the ovaries. Correlation analysis showed that inhibin , estrogen were significantly negatively correlated in both phases with FSH concentration. Inhibin had negatively correlated in follicular phase and progesterone had a negative correlation in the luteal phase. In this paper we consider the exponentiated Weibull family which has a scale parameter and two shape parameters for the application part. The Weibull family and the exponentiated exponential family are the particular cases of this family. The distribution has been compared with the two-parameter Weibull and Gamma distributions with respect to failure rates. This study showed that ovarian inhibin A and B were cleared from the circulation within 12 h of oophorectomy, whereas E2 and progesterone remain in the circulation for longer. Negative correlation between FSH, inhibin suggests that inhibins may contribute to the observed early rise in FSH after the surgical menopause.