Pharmacophore analysis for anti-malarial activity of Pyrido [1,2- a]benzimidazoles
The present work is an attempt to identify key structural features that govern the anti-malarial activity of Pyrido[1,2-a]benzimidazoles using pharmacophoric analysis. The work is based on a dataset of fifty-six molecules comprising diverse derivatives of Pyrido[1,2-a]benzimidazole. The structures were drawn, optimized and aligned using standard protocol. The final model was developed using aligned molecules. The analysis reveals that the anti-malarial activity of Pyrido[1,2-a]benzimidazoles is related with features. The analysis points out that in future modifications these features should be retained.
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Employee engagement and commitment in kakamega county government in Kenya
The purpose of this study was to investigate the influence of employee engagement on commitment in the county government of Kakamega in Kenya. The study adopted a descriptive research design with a target sample of 313 respondents drawn from a sampling comprising top management, middle management, and lower cadre employees in 12 sub counties within the county. The sampling frame was obtained by using stratified and simple random sampling techniques. From each stratum, a proportionate allocation was used to select a representative sample and the data collected by use of questionnaires. Data was analysed using descriptive, correlation and linear and multiple regression analyses. The findings obtained indicated that employee engagement had a positive and significant influence on commitment in Kakamega county government. Furthermore, the findings also revealed that vigour engagement has a higher positive and significant influence on employee commitment, with absorption giving the least influence on the predicted variable. The study recommend that county governments should endeavor to enhance engagements among their employees in order to ensure sustained commitment to the organization.
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Macular telangiectasias associated with a new choroid vessel, in one case.
Macular telangiectasias are characterized by the presence of microanevrysmal dilations around the fovea. This appellation brings together two very different entities, type 1 and type 2. We are talking in this work about Macular telangiectasia type 2. We report the case of a 48-year-old patient followed for macular telangiectasia 2, complicated by neovessels treated by anti VEGF
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List of articles published in the month of July 2020
Table of contents for the month of July 2020
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